Dysregulation of a Heme Oxygenase–Synuclein Axis in Parkinson Disease

Dysregulation of mTORC1/autophagy axis in senescence

Blood Transcriptomic Meta-analysis Identifies Dysregulation of Hemoglobin and Iron Metabolism in Parkinson’ Disease

Disrupted iron metabolism has been implicated in the pathogenesis of Parkinson's disease (PD), a progressive neurodegenerative disorder that severely affects movement and coordination, yet the molecular mechanisms underlying this association remain unknown. To this end, we performed a transcriptomic meta-analysis of four blood microarrays in PD. We observed a significant downregulation of genes...

Dysregulation of protein phosphatase 2A in parkinson disease and dementia with lewy bodies

OBJECTIVE Protein phosphatase 2A (PP2A) is a heterotrimeric holoenzyme composed of a catalytic C subunit, a structural A subunit, and one of several regulatory B subunits that confer substrate specificity. The assembly and activity of PP2A are regulated by reversible methylation of the C subunit. α-Synuclein, which aggregates in Parkinson disease (PD) and dementia with Lewy bodies (DLB), is pho...

The Effects of Whole Body Vibration on Mobility and Balance in Parkinson Disease: a Systematic Review

Whole body vibration (WBV) is a contemporary treatment modality that holds promise as an exercise training method in health–compromised individuals. A growing number of studies on individuals with Parkinson Disease are examining whether WBV improves balance and functional mobility. However, interpreting WBV studies is challenging since there is variability in the manner in which WBV interventio...

Dysregulation of non-heme iron metabolism in glial brain tumors.

OBJECTIVE To study iron exchange irregularities in experimental animals and patients with glial brain tumors to ascertain the role of the 'iron component' in glial brain tumor pathogenesis. SUBJECT AND METHODS A suspension of A.101.08 tumor cells was implanted in the cortex of the left-brain hemisphere of rats to model experimentally induced glial brain tumor. At 7 or 14 days after implantati...